NOTCH1 S2513 is critical for the regulation of NICD levels impacting the segmentation clock in hiPSC-derived PSM cells and somitoids
Hedda A. Meijer, Adam Hetherington, Sara Johnson, Rosie L. Gallagher, Izzah N. Hussein, Yuqi Weng, Jess M. Rae, Tomas E. J. C. Noordzij, Margarita Kalamara, Thomas Macartney, Lindsay Davidson, David M. A. Martin, Marek Gierliński, Paul Davies, Katharina F. Sonnen, , Jacqueline Kim Dale
This study shows that a NOTCH1 mutation affects NICD stability and disrupts segmentation clock function in hiPSC-derived PSM cells and somitoids.
Genes & Development · Sep 1, 2025Peer-reviewedDevelopmental Biology