Jacqueline Kim Dale

Cell size overrides ganglion mother cell fate specification in Drosophila

The paper shows that cell size can override fate determinants in Drosophila neuroblasts, with larger daughters retaining neuroblast-like properties despite inheriting GMC determinants.

A high throughput system reveals distinct segmentation clock phase responses in hiPSC-derived organoids

The paper develops a high-throughput system to study segmentation clock phase responses in hiPSC-derived somitoids using image-based screening and mathematical modeling.

NOTCH1 S2513 is critical for the regulation of NICD levels impacting the segmentation clock in hiPSC-derived PSM cells and somitoids

This study shows that a NOTCH1 mutation affects NICD stability and disrupts segmentation clock function in hiPSC-derived PSM cells and somitoids.

A toolkit for mapping cell identities in relation to neighbours reveals Notch-dependent heterogeneity within neuromesodermal progenitor populations

The paper introduces a toolkit to analyze cell identity patterning by comparing cells to their neighbors, revealing Notch-dependent heterogeneity in neuromesodermal progenitors.

Notch signalling influences cell fate decisions and HOX gene induction in axial progenitors

This study shows Notch signalling promotes mesodermal fate and HOX gene activation in human NMPs while inhibiting neural fate through a feedback loop with FGF.

The effect of Rosovitine on mPSM explants: a real time analysis

The paper measures the effect of Roscovitine on mPSM explants using a real-time reporter, finding increased oscillator period and differentiation rate, consistent with the clock and wavefront model requiring increased wavefront velocity.

Reconstruction of the phase dynamics of the somitogenesis clock oscillator

This study develops a computational framework to reconstruct phase dynamics of the somitogenesis clock oscillator using empirical mode decomposition and validates it with synthetic data and real-time reporter signals.

MYC activity is required for maintenance of the Neuromesodermal Progenitor signalling network and for correct timing of segmentation clock gene oscillations

This study shows MYC activity maintains neuromesodermal progenitors and regulates segmentation clock timing in mouse embryos.

CDK1 and CDK2 regulate phosphorylation-dependent NICD1 turnover and the periodicity of the segmentation clock

This study identifies CDK1 and CDK2 as regulators of NICD1 phosphorylation and turnover, showing their role in controlling segmentation clock periodicity.