A single valine to leucine switch disrupts Plasmodium falciparum AP2-G DNA binding and reveals the role of GDV1 in ap2-g activation.
Surendra K. Prajapati, J Dong, Belinda J. Morahan, Thoai Dotrang, Michelle C. Barbeau, April E. Williams, Daniel N. Hupalo, Matthew D. Wilkerson, Clifton L. Dalgard, Björn F.C. Kafsack, Llinás Manuel, Kim C. Williamson
This study identifies a valine-to-leucine mutation in AP2-G that disrupts DNA binding and sexual differentiation in Plasmodium falciparum, revealing GDV1's role in ap2-g activation.
Nature Communications · Jan 17, 2026Peer-reviewedMicrobiology