Matthew D. Wilkerson

rpMeta integrates RNA-seq and proteomics data to improve sensitivity in detecting differentially expressed genes, identifying new genes and processes in lung cancer subtypes.

This study identifies a valine-to-leucine mutation in AP2-G that disrupts DNA binding and sexual differentiation in Plasmodium falciparum, revealing GDV1's role in ap2-g activation.

This study examines spatial gene expression changes in the mouse brain after focal TBI, identifying region-specific transcriptional responses and the role of immune cells in modulating post-injury gene activity.

The paper identifies an EGFR mutation signature (mSig) that captures transcriptional features of EGFR activation in LUAD, revealing subtype-dependent oncogene activity and potential therapeutic targets.

This study shows that SOS1 inhibition with BI-3406 enhances G12C inhibitor efficacy and delays resistance in lung adenocarcinoma by targeting resistance mechanisms and drug-tolerant persister cells.

ProteoMixture estimates cell type proportions in bulk tissue proteomics data using optimized protein signatures validated on high-grade serous ovarian cancer samples.