Differential CD8+ T/NK cell-mediated reduction of HIV-1 replication after combination of ART with TIGIT or KLRG1 blockade in humanized mice
Ildefonso Sánchez‐Cerrillo, Ilya Tsukalov, M Agudo-Lera, O Popova, Patricia Fuentes, Juan Alcaín, R Gonzalez, L García-Fraile, Ignacio de los Santos, M Lázaro-Diez, David Perea, Judith Grau-Expósito, J Sevilla-Montero, Vladimir D. Vrbanac, Alejandro Benjamin Balazs, , Enrique Martín‐Gayo
This study evaluates the effect of combining antiretroviral therapy (ART) with TIGIT or KLRG1 blockade in humanized mice, showing improved HIV-1 suppression and delayed viral rebound.
bioRxiv · Sep 11, 2025 · PreprintImmunology