Vladimir D. Vrbanac

This paper uses humanized mice to study how HIV resistance to broadly neutralizing antibodies (bNAbs) affects the efficacy of AAV-delivered immunotherapy, finding that escape mutation fitness costs and resistance benefits determine therapeutic success.

This study evaluates the effect of combining antiretroviral therapy (ART) with TIGIT or KLRG1 blockade in humanized mice, showing improved HIV-1 suppression and delayed viral rebound.

This study identifies immune signatures associated with SARS-CoV-2 infection resolution in human lung tissues using a humanized mouse model.

Combining dendritic cell stimulation with anti-TIGIT antibodies enhances memory NK cell cytotoxicity against HIV-1 infected CD4+ T cells in vitro and in vivo.

The paper shows that fetal lung contains hemogenic endothelial cells capable of undergoing endothelial to hematopoietic transition to generate de-novo hematopoietic stem and progenitor cells.