Ilya Tsukalov

IFI16/AIM2 inflammasomes control Gal-9 and PVR in myeloid cells from PWH and their targeting improves immunotherapy against HIV-1

The paper shows that inhibiting IFI16 and AIM2 in myeloid cells from HIV-1 patients reduces Gal-9 and PVR, enhancing CD8+ T-cell responses against HIV-1.

Differential CD8+ T/NK cell-mediated reduction of HIV-1 replication after combination of ART with TIGIT or KLRG1 blockade in humanized mice

This study evaluates the effect of combining antiretroviral therapy (ART) with TIGIT or KLRG1 blockade in humanized mice, showing improved HIV-1 suppression and delayed viral rebound.

Combined Dendritic Cell And Anti-TIGIT Immunotherapy Potentiate Trail+ Memory NK Cells Against HIV-1 Infected Cells

Combining dendritic cell stimulation with anti-TIGIT antibodies enhances memory NK cell cytotoxicity against HIV-1 infected CD4+ T cells in vitro and in vivo.

Sequential IL-15 and TGF-β1 stimulation expands reprogrammed CD103⁺CD39⁺ effector CD8⁺T cells and enhances HIV control

This study shows that sequential IL-15 and TGF-β1 stimulation expands HIV-specific CD8+T cells with enhanced effector functions, improving HIV control during treatment interruption.