Spatial proteomics reveals CD8+ T cell signatures and cellular niches associated with active HIV-1 replication in lymph nodes
Candace C. Liu, Marta Calvet‐Mirabent, Angie Spence…·Enrique Martín‐Gayo
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Consejo Superior de Investigaciones CientíficasORCID 0000-0002-2619-6086Unclaimed ORCID profile · follow to get notified of new preprints
7 papers
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Candace C. Liu, Marta Calvet‐Mirabent, Angie Spence…·Enrique Martín‐Gayo
Marta Calvet‐Mirabent, Ilya Tsukalov, Ildefonso Sánchez‐Cerrillo…·Enrique Martín‐Gayo
The paper shows that inhibiting IFI16 and AIM2 in myeloid cells from HIV-1 patients reduces Gal-9 and PVR, enhancing CD8+ T-cell responses against HIV-1.
Ana Gallego-Cortés, Nerea Sánchez-Gaona, Cristina Mancebo-Pérez…·Maria José Buzón
The paper identifies inducible HIV reservoirs in tonsillar, intestinal, and cervical tissues using tissue models, revealing tissue-specific markers and the effectiveness of different latency reversal agents.
Ildefonso Sánchez‐Cerrillo, Ilya Tsukalov, M Agudo-Lera…·Enrique Martín‐Gayo
This study evaluates the effect of combining antiretroviral therapy (ART) with TIGIT or KLRG1 blockade in humanized mice, showing improved HIV-1 suppression and delayed viral rebound.
Sara González-García, María Jesús García-León, Marina García-Peydró…·Marı́a L. Toribio
This study identifies miR-15b/16-2 as tumor suppressors in T-cell acute lymphoblastic leukemia by showing their role in inhibiting proliferation and promoting apoptosis through repression of BCL-2 and CYCLIN D3.
Ildefonso Sánchez‐Cerrillo, María Agudo-Lera, Olga Popova…·Enrique Martín‐Gayo
Combining dendritic cell stimulation with anti-TIGIT antibodies enhances memory NK cell cytotoxicity against HIV-1 infected CD4+ T cells in vitro and in vivo.
Cristina Mancebo-Pérez, Aleix Benítez-Martínez, Ilya Tsukalov…·Meritxell Genescà
This study shows that sequential IL-15 and TGF-β1 stimulation expands HIV-specific CD8+T cells with enhanced effector functions, improving HIV control during treatment interruption.