Using CRISPR barcoding as a molecular clock to capture dynamic processes at single-cell resolution
Yolanda Andres-Lopez, Alice Santambrogio, Ioannis Kafetzopoulos, Christopher D. Todd, Carla El Khouri-Gonzalez, J-Elliot Gonzalez-Alvarez, Celia Alda-Catalinas, Stephen J. Clark, Wolf Reik, Irene Hernando-Herraez
This paper introduces scDynaBar, a method using CRISPR barcoding to track temporal cellular events at single-cell resolution, showing the transient nature of the 2C-like state in mESCs.
Genome Research · May 1, 2026Peer-reviewedCell Biology