Ioannis Kafetzopoulos

This paper introduces scDynaBar, a method using CRISPR barcoding to track temporal cellular events at single-cell resolution, showing the transient nature of the 2C-like state in mESCs.

This study shows that DNMT1 loss causes hypomethylation in late replicating domains but also leads to hypermethylation in some domains due to DNMT3A activity, altering chromatin states.

This paper introduces a physics-based model explaining how cells maintain histone methylation patterns after division, validated by simulations and experimental data.

The paper identifies epigenetically primed enhancers in early embryonic development and shows their role in regulating developmental gene networks across species.

This study shows that DNMT3B PWWP mutations cause hypermethylation of heterochromatin marked by H3K9me3, disrupting DNA methylation homeostasis and contributing to ICF syndrome, cancer, and aging.

The paper uses single-molecule long-read DNA methylation data to show that bulk-level metrics underestimate heterogeneity in the methylome, particularly in heterochromatic regions.

The paper shows de novo DNA methyltransferases in colorectal cancer target H3K36me3-marked CpG islands, similar to normal tissues, rather than sequence-specific CpG islands.