Author

J. A. Borghans

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Assay:flow cytometry· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1

Frequent Co-Authors

J. Drylewicz· 2 shared K. Tesselaar· 2 shared L. Borkner· 2 shared L. Cicin-Sain· 2 shared M. Baliu-Pique· 2 shared R. j. De Boer· 2 shared X. Zheng· 2 shared A. C. Swain· 1 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersImmunology

J. Drylewicz

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Author profile →

3 papers

Recent·Most cited

Age-dependent normalisation functions for T-lymphocytes in healthy individuals

J. Schroeter, J. A. Borghans, M. W. Bitter, J. J. van Dongen, R. j. De Boer

This study develops age-dependent normalization functions for T-lymphocyte subsets in healthy Dutch individuals from infancy to adulthood, enabling quantification of changes in disease contexts.

bioRxiv · Dec 1, 2021 · PreprintImmunology

Turnover of MCMV-expanded CD8+ T-cells is similar to that of memory phenotype T-cells and independent of the magnitude of the response

M. Baliu-Pique, J. Drylewicz, X. Zheng, L. Borkner, A. C. Swain, S. Otto, R. J. de Boer, K. Tesselaar, L. Cicin-Sain, J. A. Borghans

The paper compares the turnover rates of CMV-specific CD8+ T-cells to memory phenotype CD8+ T-cells, finding they are similar regardless of response magnitude.

bioRxiv · Nov 3, 2021 · PreprintImmunology

Off-target effects of Cre recombinase reveal limits of adoptive T cell transfers and persistent proliferation of effector CD8 T-cells

L. Borkner, A. Drabig, X. Zheng, J. Drylewicz, T. Marandu, M. Baliu-Pique, S. van Duikeren, R. Arens, K. Tesselaar, J. A. Borghans, L. Cicin-Sain

The paper shows that effector memory T-cells (TEM) proliferate during persistent CMV infection, maintaining memory inflation, while central memory T-cells (TCM) do not proliferate as much.

bioRxiv · Dec 20, 2018 · PreprintImmunology