S. Otto

The maintenance of genetic polymorphism underlying sexually antagonistic traits

The paper models how sexual antagonism affects genetic polymorphism in continuous traits, finding that stabilizing selection often leads to monomorphic outcomes, making polymorphism rare and transient.

A Pandemic-Scale Ancestral Recombination Graph for SARS-CoV-2

The paper infers an Ancestral Recombination Graph for 2.48 million SARS-CoV-2 genomes to account for recombination, providing a more accurate representation of viral genealogy than traditional trees.

In Silico, Brain Mesh Platform for Computing Topographic Dependent Internal Facets

The paper develops a brain modeling platform using patient MRI data to simulate drug dispersal and fluid flow in healthy and diseased brains, focusing on glioblastoma.

MRI-to-Synthetic 3D Gel Brain: Proof-of-Concept Fabrication For Intra-Parenchymal Diffusion Studies

This paper demonstrates a method to create synthetic 3D gel brains from MRI data to study intra-parenchymal diffusion, showing improved representation of diffusion profiles compared to simple gel models.

Parental population range expansion before secondary contact promotes heterosis

The paper shows that historical parental population expansion before secondary contact can lead to heterosis in hybrids by reducing the negative effects of Bateson-Dobzhansky-Muller incompatibilities.

The phoenix hypothesis of speciation

The paper uses simulations to show that extreme environmental changes can accelerate speciation through evolutionary rescue, leading to reproductive isolation, but also parallel mutations when adaptation potential is limited.

Turnover of MCMV-expanded CD8+ T-cells is similar to that of memory phenotype T-cells and independent of the magnitude of the response

The paper compares the turnover rates of CMV-specific CD8+ T-cells to memory phenotype CD8+ T-cells, finding they are similar regardless of response magnitude.

GENE DRIVES ACROSS ENGINEERED FITNESS VALLEYS: MODELING A DESIGN TO PREVENT DRIVE SPILLOVER

The paper models a gene drive system that transitions from a low threshold to high threshold drive to prevent spillover, showing it can achieve stable local suppression without transgenic spread.

Loss of α7 nicotinic acetylcholine receptors in GABAergic interneurons causes sex-dependent impairments in postnatal neurogenesis and cognitive and social behavior

This study shows loss of α7 nAChRs in GABAergic interneurons reduces postnatal neurogenesis and causes sex-dependent behavioral changes in mice.