Inflammasome-mediated antagonism of type I interferon enhances Rickettsia pathogenesis
T. P. Burke, P. Engström, R. A. Chavez, J. A. Fonbuena, R. E. Vance, M. D. Welch
This study shows that Rickettsia parkeri is sensitive to type I interferon, which is counteracted by inflammasome-mediated pyroptosis, revealing a trade-off in innate immunity.
bioRxiv · Jul 11, 2019Immunology