R. E. Vance

Interleukin-1 receptor antagonist is a conserved factor for exacerbating tuberculosis susceptibility

The paper identifies IL-1 receptor antagonist as a conserved factor limiting Mtb control across mice, non-human primates, and humans.

The Inflammasome Pathway is Activated by Dengue Virus Non-structural Protein 1 and is Protective During Dengue Virus Infection

This study shows DENV NS1 activates inflammasomes in macrophages, leading to IL-1β release without pyroptosis, and that this pathway is protective against DENV infection.

Impaired aldehyde detoxification caused by a common human polymorphism promotes anti-bacterial immunity

The paper shows ALDH2 deficiency enhances anti-bacterial immunity by increasing aldehyde levels that kill pathogens and boost inflammatory responses.

A hierarchy of cell death pathways confers layered resistance to shigellosis in mice

The paper shows that multiple cell death pathways work together to protect mice from Shigella infection, with some pathways compensating for others when one is removed.

Deficiency in Galectin-3, -8, and -9 impairs immunity to chronic Mycobacterium tuberculosis infection but not acute infection with multiple intracellular pathogens

Early cellular mechanism of type I interferon-driven susceptibility to tuberculosis

This study identifies interstitial macrophages and plasmacytoid dendritic cells as key producers of type I IFN during Mtb infection, showing their role in driving tuberculosis pathogenesis through IFN-driven mechanisms.

Host specific sensing of coronaviruses and picornaviruses by the CARD8 inflammasome

This study identifies CARD8 as a sensor for viral proteases, showing it activates inflammasomes in response to coronavirus 3CLpro and can be modulated by genetic variation.

Coenzyme A governs proinflammatory macrophage metabolism

This study shows that exogenous CoA enhances TLR-driven proinflammatory and antimicrobial responses in macrophages by promoting oxidative metabolism and histone acetylation.

Pyroptosis-dependent and -independent cross-priming of CD8+ T cells by intestinal epithelial cell-derived antigen

The paper shows that IEC-derived antigens can cross-prime CD8+ T cells through both pyroptosis-dependent and -independent pathways involving cDC1.

The cyclic dinucleotide 2'3'-cGAMP induces a broad anti-bacterial and anti-viral response in the sea anemone Nematostella vectensis

This study shows that 23-cGAMP induces both anti-viral and anti-bacterial gene expression in the sea anemone Nematostella vectensis, suggesting an ancestral role for cyclic dinucleotide signaling in immunity.

NAIP-NLRC4-deficient mice are susceptible to shigellosis

This study shows that NAIP-NLRC4-deficient mice are susceptible to Shigella infection, mimicking human shigellosis, and reveals that inflammasome-mediated cell death protects against the disease.

Role of the transcriptional regulator SP140 in resistance to bacterial infections via repression of type I interferons

This study identifies SP140 as a repressor of type I interferons that enhances resistance to bacterial infections like Legionella pneumophila and Mycobacterium tuberculosis.

New mutant mouse models clarify the role of NAIPs, phosphorylation, NLRP3, and tumors in NLRC4 inflammasome activation

This study uses genetic models to show that NLRC4 phosphorylation and NLRP3 do not play a role in NAIP/NLRC4 inflammasome activation or anti-tumor responses.

Inflammasome-mediated antagonism of type I interferon enhances Rickettsia pathogenesis

This study shows that Rickettsia parkeri is sensitive to type I interferon, which is counteracted by inflammasome-mediated pyroptosis, revealing a trade-off in innate immunity.

Functional degradation: a mechanism of NLRP1 inflammasome activation by diverse pathogen enzymes

The paper identifies proteasome-mediated degradation of NLRP1B as a mechanism by which two distinct pathogen enzymes activate the inflammasome.