R. A. Chavez

Risk assessment predicts most of the salmonellosis risk in raw chicken parts is concentrated in those few products with high-levels of high-virulent serotypes of Salmonella

The paper assesses salmonellosis risk in raw chicken parts using microbial risk assessment, finding most illnesses are attributed to a small fraction of products with high levels of high-virulent Salmonella serotypes.

A hierarchy of cell death pathways confers layered resistance to shigellosis in mice

The paper shows that multiple cell death pathways work together to protect mice from Shigella infection, with some pathways compensating for others when one is removed.

NAIP-NLRC4-deficient mice are susceptible to shigellosis

This study shows that NAIP-NLRC4-deficient mice are susceptible to Shigella infection, mimicking human shigellosis, and reveals that inflammasome-mediated cell death protects against the disease.

New mutant mouse models clarify the role of NAIPs, phosphorylation, NLRP3, and tumors in NLRC4 inflammasome activation

This study uses genetic models to show that NLRC4 phosphorylation and NLRP3 do not play a role in NAIP/NLRC4 inflammasome activation or anti-tumor responses.

IRG1 and iNOS act redundantly with other interferon gamma induced factors to restrict intracellular replication of Legionella pneumophila.

The paper identifies six IFN-gamma-induced genes, including IRG1 and iNOS, that redundantly restrict L. pneumophila replication in macrophages.

Inflammasome-mediated antagonism of type I interferon enhances Rickettsia pathogenesis

This study shows that Rickettsia parkeri is sensitive to type I interferon, which is counteracted by inflammasome-mediated pyroptosis, revealing a trade-off in innate immunity.