HIV-1 Vpu restricts Fc-mediated effector functions in vivo
J. Prevost, S. P. Anand, J. K. Rajashekar, J. Richard, G. Goyette, H. Medjahed, G. Gendron-Lepage, H.-C. Chen, Y. Chen, J. A. Horwitz, M. W. Grunst, S. Zolla-Pazner, B. F. Haynes, D. R. Burton, R. A. Flavell, , A. Finzi
This study shows that HIV-1 Vpu reduces nnAb recognition and ADCC resistance, with nnAb Fc-effector functions dependent on Env's open conformation.
bioRxiv · Feb 21, 2022Microbiology