Author

M. W. Grunst

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 5 Approach:experimental assay· 4 Organism:human· 3 Assay:proteomics· 3 Research Focus:drug response / drug discovery· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1

Frequent Co-Authors

A. Finzi· 3 shared G. Goyette· 3 shared J. Prevost· 3 shared J. Richard· 3 shared M. Pazgier· 3 shared P. D. Uchil· 3 shared P. Kumar· 3 shared S. P. Anand· 3 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersMicrobiology

A. Finzi

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Potent antibody-dependent cellular cytotoxicity of a V2-specific antibody is not sufficient for protection of macaques against SIV challenge

M. W. Grunst, H. M. Gil, A. G. Grandea, B. J. Snow, R. Andrabi, R. Nedellec, I. Burton, N. M. Clark, S. K. Janaka, N. K. Keles, R. V. Moriarty, A. M. Weiler, S. Capuano, C. M. Fennessey, T. C. Friedrich, , D. T. Evans

This study shows that potent antibody-dependent cellular cytotoxicity (ADCC) by a V2-specific antibody is insufficient to protect macaques against SIV challenge, but reduced viral loads were observed with a neutralization-sensitive SIV variant.

bioRxiv · Nov 14, 2023Microbiology

Asymmetric HIV-1 envelope trimers bound to one and two CD4 molecules are intermediates during membrane binding

W. Li, E. Nand, Z. Qin, M. W. Grunst, J. R. Grover, J. W. Bess, J. D. Lifson, M. B. Zwick, H. D. Tagare, P. D. Uchil, W. Mothes

The paper uses cryo-ET to study HIV-1 Env-CD4 interactions on membranes, revealing asymmetric trimers bound to one or two CD4 molecules as intermediates in virus binding.

bioRxiv · Dec 23, 2022Microbiology

Molecular basis for antiviral activity of pediatric neutralizing antibodies targeting SARS-CoV-2 Spike receptor binding domain

Y. Chen, J. Prevost, I. Ullah, H. Romero, V. Lisi, W. D. Tolbert, J. R. Grover, S. Ding, S. Y. Gong, G. Beaudoin-Bussieres, R. Gasser, M. Benlarbi, D. Vezina, S. P. Anand, D. Chatterjee, , A. Finzi

This study identifies two potent neutralizing antibodies, EH3 and EH8, from a pediatric patient that cross-neutralize SARS-CoV-2 variants and provide in vivo protection against the Delta VOC.

bioRxiv · Jul 27, 2022 · PreprintMicrobiology

HIV-1 Vpu restricts Fc-mediated effector functions in vivo

J. Prevost, S. P. Anand, J. K. Rajashekar, J. Richard, G. Goyette, H. Medjahed, G. Gendron-Lepage, H.-C. Chen, Y. Chen, J. A. Horwitz, M. W. Grunst, S. Zolla-Pazner, B. F. Haynes, D. R. Burton, R. A. Flavell, , A. Finzi

This study shows that HIV-1 Vpu reduces nnAb recognition and ADCC resistance, with nnAb Fc-effector functions dependent on Env's open conformation.

bioRxiv · Feb 21, 2022Microbiology

Structural Basis and Mode of Action for Two Broadly Neutralizing Antibodies Against SARS-CoV-2 Emerging Variants of Concern

W. Mothes, W. Li, Y. Chen, J. Prevost, I. Ullah, M. Lu, S. Y. Gong, A. Tauzin, R. Gasser, D. Vezina, S. P. Anand, G. Goyette, D. Chaterjee, S. Ding, W. D. Tolbert, , A. Finzi

This study characterizes two SARS-CoV-2 antibodies effective against variants, showing their structural basis and mechanisms of neutralization.

bioRxiv · Aug 2, 2021Microbiology