Gut regulatory T cells mediate immunological tolerance in Salmonella Typhimurium-infected superspreader hosts by suppressing cytotoxic activity of T cells.
L. Moura Massis, S. Ruddle, S. M. Brewer, R. Schade, R. Narasimhan, J. D. Honeycutt, T. H. Pham, J. A. McKenna, S. W. Brubaker, P. Chairatana, J. A. Klein, M. d. M. Margalef-Catala, M. R. Amieva, J. G. Vilches-Moure, D. M. Monack
The paper identifies regulatory T cells (Tregs) as critical for maintaining immunological tolerance in superspreader hosts infected with Salmonella Typhimurium by suppressing cytotoxic T-cell activity.
bioRxiv · Jul 16, 2021 · PreprintImmunology