Author

J. A. McKenna

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:bacteria (other)· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:flow cytometry· 1 Research Focus:gene regulatory network inference· 1 Assay:imaging· 1

Frequent Co-Authors

B. Becerra Larios· 1 shared D. K. Chan· 1 shared D. M. Monack· 1 shared G. P. Munson· 1 shared H. J. Wing· 1 shared J. A. Klein· 1 shared J. D. Honeycutt· 1 shared J. G. Vilches-Moure· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperMicrobiology

B. Becerra Larios

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Author profile →

2 papers

Recent·Most cited

The AraC/XylS protein MxiE and its co-regulator IpgC control a negative feedback loop in the transcriptional cascade that regulates type III secretion in Shigella flexneri

J. A. McKenna, M. M. Karney, D. K. Chan, N. Weatherspoon-Griffin, B. Becerra Larios, M. C. Pilonieta, G. P. Munson, H. J. Wing

This paper identifies a negative feedback loop involving MxiE and IpgC that down-regulates the virB promoter in Shigella flexneri, counteracting VirF activation.

bioRxiv · Apr 20, 2022Microbiology

Gut regulatory T cells mediate immunological tolerance in Salmonella Typhimurium-infected superspreader hosts by suppressing cytotoxic activity of T cells.

L. Moura Massis, S. Ruddle, S. M. Brewer, R. Schade, R. Narasimhan, J. D. Honeycutt, T. H. Pham, J. A. McKenna, S. W. Brubaker, P. Chairatana, J. A. Klein, M. d. M. Margalef-Catala, M. R. Amieva, J. G. Vilches-Moure, D. M. Monack

The paper identifies regulatory T cells (Tregs) as critical for maintaining immunological tolerance in superspreader hosts infected with Salmonella Typhimurium by suppressing cytotoxic T-cell activity.

bioRxiv · Jul 16, 2021 · PreprintImmunology