Author

S. Ruddle

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:flow cytometry· 1 Assay:imaging· 1

Frequent Co-Authors

D. M. Monack· 2 shared A. C. Cutter· 1 shared J. A. Klein· 1 shared J. A. McKenna· 1 shared J. D. Honeycutt· 1 shared J. G. Vilches-Moure· 1 shared L. M. Massis· 1 shared L. Moura Massis· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersMicrobiology

D. M. Monack

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Multi-omics reveal Salmonella-liberated dietary L-arabinose promotes expansion in superspreaders

S. Ruddle, L. M. Massis, A. C. Cutter, D. M. Monack

The paper shows diet-derived L-arabinose promotes Salmonella expansion in superspreader hosts through a novel enzyme-mediated pathway.

bioRxiv · Jul 19, 2022 · PreprintMicrobiology

Gut regulatory T cells mediate immunological tolerance in Salmonella Typhimurium-infected superspreader hosts by suppressing cytotoxic activity of T cells.

L. Moura Massis, S. Ruddle, S. M. Brewer, R. Schade, R. Narasimhan, J. D. Honeycutt, T. H. Pham, J. A. McKenna, S. W. Brubaker, P. Chairatana, J. A. Klein, M. d. M. Margalef-Catala, M. R. Amieva, J. G. Vilches-Moure, D. M. Monack

The paper identifies regulatory T cells (Tregs) as critical for maintaining immunological tolerance in superspreader hosts infected with Salmonella Typhimurium by suppressing cytotoxic T-cell activity.

bioRxiv · Jul 16, 2021 · PreprintImmunology