Author

J. A. Kretz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Assay:organoid / primary culture· 1

Frequent Co-Authors

A. E. Moor· 2 shared X. Ficht· 2 shared A. Khandekar· 1 shared A. Lafzi· 1 shared A. Sendoel· 1 shared C. Borrelli· 1 shared D. Eletto· 1 shared E. Guido Vinzoni· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersCancer Biology

A. E. Moor

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2 papers

Recent·Most cited

In vivo single-cell CRISPR uncovers distinct TNF-alphaprograms in clonal expansion and tumorigenesis

P. F. Renz, U. Ghoshdastider, S. Baghai Sain, F. Valdivia-Francia, A. Khandekar, M. Ormiston, M. Bernasconi, J. A. Kretz, M. Lee, K. Hyams, M. Forny, M. Pohly, X. Ficht, S. J. Ellis, A. E. Moor, A. Sendoel

This study uses in vivo single-cell CRISPR to identify distinct TNF-α programs in clonal expansion and tumorigenesis, showing their roles in epithelial transformation and tumor initiation.

bioRxiv · Jul 13, 2023 · PreprintCancer Biology

In vivo screening of tumor-hepatocyte interactions identifies Plexin B2 as a gatekeeper of liver metastasis

C. Borrelli, M. Roberts, D. Eletto, A. Lafzi, J. A. Kretz, H. Fazilaty, M.-D. Hussherr, E. Guido Vinzoni, K. Handler, J. Michler, S. Adivarahan, S. Piscuoglio, X. Ficht, A. E. Moor

The paper identifies Plexin B2 in hepatocytes as a critical regulator of liver metastasis by promoting epithelial traits in tumor cells through Rac1 signaling.

bioRxiv · May 15, 2023 · PreprintCancer Biology