S. Piscuoglio

A double-negative prostate cancer subtype is vulnerable to SWI/SNF-targeting degrader molecules

This study identifies a SWI/SNF-targeting therapy effective against a double-negative prostate cancer subtype, showing it reduces viability in both AR-dependent and WNT-dependent models.

In vivo screening of tumor-hepatocyte interactions identifies Plexin B2 as a gatekeeper of liver metastasis

The paper identifies Plexin B2 in hepatocytes as a critical regulator of liver metastasis by promoting epithelial traits in tumor cells through Rac1 signaling.

Patient-derived organoids identify tailored therapeutic options and determinants of plasticity in sarcomatoid urothelial bladder cancer

Elevated arginine levels in liver tumors promote metabolic reprogramming and tumor growth

The paper shows elevated arginine levels in liver tumors drive metabolic reprogramming and tumor growth through feedback loops involving ASNS and arginase 1.

Minor intron splicing efficiency increases with the development of lethal prostate cancer

The paper shows that minor intron splicing efficiency increases in castration-resistant prostate cancer and that inhibiting the minor spliceosome reduces tumor burden.

Proteogenomic characterization of hepatocellular carcinoma

This study identifies differentially regulated pathways and candidate driver genes in hepatocellular carcinomas through proteogenomic analysis across clinical stages and etiologies.

Patient-derived xenografts and organoids model therapy response in prostate cancer

This study develops a patient-derived xenograft (PDX) model of prostate cancer that mimics disease stages and identifies drug sensitivities in metastatic cases.

Mapping of m6A and Its Regulatory Targets in Prostate Cancer Reveals a METTL3-low Induction of Therapy Resistance

The paper maps m6A in prostate cancer and shows METTL3-low promotes therapy resistance through upregulated extracellular matrix proteins and hepatocyte nuclear factor-driven gene signatures.

Role of Specialized mSWI/SNF Complexes in Prostate Cancer Lineage Plasticity

The paper investigates the role of mSWI/SNF complexes in NEPC lineage plasticity using patient data and cell models, finding deregulated subunits and SMARCA4 overexpression linked to aggressive disease.

Colitis is associated with loss of LHPP and up-regulation of histidine phosphorylation in intestinal epithelial cells

The paper shows that intestinal inflammation correlates with loss of LHPP and increased histidine phosphorylation in IECs, but LHPP loss alone does not cause inflammation.

GATA3 and MDM2 are synthetic lethal in estrogen receptor-positive breast cancers

This study identifies GATA3 and MDM2 as synthetic lethal in ER-positive breast cancers, showing MDM2 inhibition can target GATA3-deficient tumors via the PI3K/Akt/mTOR pathway.

The Genomic Landscape of Prostate Cancer Brain Metastases

This study identifies genomic alterations in prostate cancer brain metastases, highlighting mutations in NF1 and RICTOR and DNA homologous repair defects as potential drivers.

AGO1x prevents dsRNA-induced interferon signaling to promote breast cancer cell proliferation

This study identifies AGO1x, a nuclear Argonaute isoform, as a suppressor of dsRNA-induced interferon signaling that promotes breast cancer cell proliferation.