A. E. Moor

In vivo single-cell CRISPR uncovers distinct TNF-alphaprograms in clonal expansion and tumorigenesis

This study uses in vivo single-cell CRISPR to identify distinct TNF-α programs in clonal expansion and tumorigenesis, showing their roles in epithelial transformation and tumor initiation.

In vivo screening of tumor-hepatocyte interactions identifies Plexin B2 as a gatekeeper of liver metastasis

The paper identifies Plexin B2 in hepatocytes as a critical regulator of liver metastasis by promoting epithelial traits in tumor cells through Rac1 signaling.

Single-cell transcriptomics analysis reveals extracellular matrix remodelling in carious human dental pulp

This study uses single-cell RNA sequencing to show ECM remodelling and fibrosis-like changes in carious human dental pulp.

The vascular gene Apold1 is dispensable for normal development but controls angiogenesis under pathological conditions

This study shows that Apold1 is not essential for normal angiogenesis but is critical for revascularization under ischemic conditions and tumor growth.

Fate and plasticity of SARS-CoV-2-specific B cells during memory and recall response in humans

The paper tracks SARS-CoV-2-specific memory B cell fate transitions in humans, showing single clones can adopt distinct functional trajectories during memory and recall responses.

Single-cell RNA sequencing unveils intestinal eosinophil development and specialization

The paper uses single-cell transcriptomics and flow cytometry to identify five eosinophil subsets in mice, revealing their developmental stages and specialized functions in the GI tract.

A single cell atlas of human teeth

This study creates a single-cell atlas of human teeth, revealing cellular heterogeneity and highlighting microenvironmental differences as key drivers of stem cell function.

Discrete regulation of b-catenin-mediated transcription governs identity of intestinal epithelial stem cells

This study shows that discrete regulation of β-catenin-mediated transcription by co-factors determines the identity and proliferative behavior of intestinal epithelial stem cells.

Lgr5+ telocytes are a signaling hub at the intestinal villus tip

The paper identifies Lgr5+ telocytes at the intestinal villus tip as signaling hubs that regulate epithelial gene zonation through Bmp and Wnt5a signals.