Author

J. A. M. Mercer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:deep learning· 1 Approach:experimental assay· 1 Assay:protein structure· 1

Frequent Co-Authors

D. R. Liu· 2 shared A. Bera· 1 shared A. Choudhary· 1 shared A. Deb· 1 shared A. H.-W. Yeh· 1 shared A. Kang· 1 shared A. Sadagopan· 1 shared B. Coventry· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiochemistry

D. R. Liu

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2 papers

Recent·Most cited

BiochemistrybioRxivNov 1, 2023

Small-molecule binding and sensing with a designed protein family

G. R. Lee, S. J. Pellock, C. Norn…·D. Baker

This paper designs a protein family that binds and senses small molecules using deep learning and physics-based methods, achieving nanomolar sensitivity for cortisol.

DOI 10.1038/s41467-026-70953-8

protein structuredeep learning

𝕏 PostBluesky

Pharmacology & ToxicologybioRxivNov 18, 2021

Proteolysis Targeting Chimeras With Reduced Off-targets

T. M. Nguyen, V. Sreekanth, A. Deb…·A. Choudhary

This study develops a platform to identify off-target degradation of ZF proteins by PROTACs and identifies design rules to reduce off-target effects using pomalidomide analogs.

DOI 10.1038/s41557-023-01379-8

experimental assaydrug response / drug discovery

𝕏 PostBluesky