Author

T. M. Nguyen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Biochemistry· 2 Bioengineering· 1 Cancer Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:drug response / drug discovery· 3 Organism:human· 3 Organism:E. coli· 2 Organism:C. elegans· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

S. Telek· 2 shared A. Bruckner· 1 shared A. Choudhary· 1 shared A. Christiano· 1 shared A. Cramer· 1 shared A. Deb· 1 shared A. Di Ruscio· 1 shared A. E. Oro· 1 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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2 shared papersMicrobiology

S. Telek

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

A scalable, GMP-compatible, autologous organotypic cell therapy for Dystrophic Epidermolysis Bullosa

G. Neumayer, J. Torkelson, S. Li, K. McCarthy, H. Zhen, M. Vangipuram, J. Jackow, A. Rami, C. Hansen, Z. Guo, S. Gaddam, A. Pappalardo, L. Li, A. Cramer, K. Roy, , A. E. Oro

This paper develops a scalable, GMP-compatible cell therapy for Dystrophic Epidermolysis Bullosa using CRISPR-corrected iPS cells to generate functional skin grafts.

bioRxiv · Feb 28, 2023 · PreprintBioengineering

MYXOBACTERIA FROM VIETNAM: ISOLATION, PHYLOGENETIC ANALYSIS AND BIOPROSPECTION

Y. T. N. Nguyen, C. D. Duong, H. T. K. Nguyen, C. P. Nguyen, N. T. Vo, L. T. L. Dinh, N. L. B. Nguyen, T. M. Nguyen, N. D. Nguyen, A. T. Nguyen

The paper isolates and characterizes myxobacteria from Vietnam, identifies their phylogeny, and evaluates their antioxidant and antimicrobial potential.

bioRxiv · Apr 27, 2022Microbiology

Proteolysis Targeting Chimeras With Reduced Off-targets

T. M. Nguyen, V. Sreekanth, A. Deb, P. Kokkonda, P. K. Tiwari, K. A. Donovan, V. M. Shoba, S. K. Chaudhary, J. A. M. Mercer, S. Lai, A. Sadagopan, M. Jan, E. S. Fischer, D. R. Liu, B. L. Ebert, A. Choudhary

This study develops a platform to identify off-target degradation of ZF proteins by PROTACs and identifies design rules to reduce off-target effects using pomalidomide analogs.

bioRxiv · Nov 18, 2021Pharmacology & Toxicology

Investigation of the futalosine pathway for menaquinone biosynthesis as a novel target in the inhibition of Chlamydia trachomatis infection

B. M. Dudiak, T. M. Nguyen, D. Needham, T. C. Outlaw, D. G. McCafferty

This study identifies the futalosine pathway as a target for inhibiting Chlamydia trachomatis infection using docosahexaenoic acid and shows that menaquinone-7 is essential for its survival.

bioRxiv · Oct 26, 2021 · PreprintBiochemistry

Structural insights into the role of Dicer-related helicase 3 in RNAi in Caenorhabditis elegans.

K. Li, J. Zheng, M. Wirawan, T. M. Nguyen, O. Fedorova, P. Griffin, A. M. Pyle, D. Luo

This study determines the crystal structures of DRH-3 domains bound to RNA, revealing structural features that explain its role in RNAi and evolutionary divergence from Dicer-like helicases.

bioRxiv · Mar 14, 2021 · PreprintBiochemistry

Reducing phenotypic instabilities of microbial population during continuous cultivation based on cell switching dynamics

T. M. Nguyen, S. Telek, A. Zicler, J. A. Martinez, B. Zacchetti, J. Kopp, C. Slouka, C. Herwig, A. Gruenberger, D. Frank

This paper demonstrates that allowing microbial cells to switch phenotypes around a threshold, rather than enforcing a fixed trajectory, leads to more stable population behavior during continuous cultivation.

bioRxiv · Jan 13, 2021Microbiology

Myeloid lncRNA LOUP Mediates Opposing Regulatory Effects of RUNX1 and RUNX1-ETO in t(8;21) AML

B. Q. Trinh, S. Ummarino, A. K. Ebralidze, E. van der Kouwe, M. A. Bassal, T. M. Nguyen, R. Coffey, D. E. Tenen, E. Fabiani, C. Gurnari, C.-S. Wu, V. E. Angarica, Y. Zhang, L. Ying, H. Yang, , D. G. Tenen

The paper identifies the long noncoding RNA LOUP as a mediator of RUNX1 and RUNX1-ETO effects in t(8;21) AML, showing it promotes myeloid differentiation and inhibits cell growth by regulating PU.1 expression.

bioRxiv · Jul 24, 2020Cancer Biology

Assessing the virulence of Cryptococcus neoformans causing meningitis in HIV infected and uninfected patients in Vietnam

T. T. Lam, D. Toffaletti, J. Tenor, C. Giamberardino, G. Sempowski, Y. Asfaw, T. H. Phan, A. V. Duong, T. M. Nguyen, L. P. H. Nguyen, C. T. H. Tran, P. M. Ashton, J. Beardsley, C. V. V. Nguyen, G. E. Thwaites, , J. N. Day

This study compares the virulence of Cryptococcus neoformans ST5 and non-ST5 isolates in HIV-infected and uninfected patients in Vietnam, finding ST5 isolates show greater variability and initial inflammatory response but lower fungal burden in mice.

bioRxiv · Feb 19, 2020Microbiology

Segregostat: A novel concept to control phenotypic diversification dynamics on the example of Gram-negative bacteria

H. Sassi, T. M. Nguyen, S. Telek, G. Gosset, A. Grunberger, F. Delvigne

The paper introduces a method called segregostat to control phenotypic diversification in microbial populations by using glucose pulses based on real-time analysis of membrane permeability.

bioRxiv · Feb 8, 2019Microbiology