Author

V. Sreekanth

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1 Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 2 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Organism:human· 1

Frequent Co-Authors

A. Choudhary· 4 shared B. L. Ebert· 2 shared D. Lim· 2 shared D. R. Liu· 2 shared M. Jan· 2 shared P. Kokkonda· 2 shared A. Baublis· 1 shared A. Deb· 1 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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4 shared papersBiochemistry

A. Choudhary

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Photoswitchable Molecular Glues Enable Optical Control of Transcription Factor Degradation

C. J. Arp, M. Reynders, V. Sreekanth, P. Kokkonda, M. Pagano, A. Choudhary, D. Trauner

This paper introduces PHOIMiDs, photoswitchable immunomodulatory drugs that degrade Ikaros and Aiolos in a light-dependent manner with high selectivity.

bioRxiv · Apr 9, 2023 · PreprintBiochemistry

A molecular glue approach to control the half-life of CRISPR-based technologies

V. Sreekanth, M. Jan, K. T. Zhao, D. Lim, J. R. Davis, M. McConkey, V. Kovalcik, S. Barkal, B. K. Law, J. Fife, R. Tian, M. E. Vinyard, B. Becerra, M. E. Kampmann, R. I. Sherwood, , A. Choudhary

This paper introduces a molecular glue approach using pomalidomide to control the half-life of CRISPR-based technologies, enabling precise regulation of their activity and therapeutic potential.

bioRxiv · Mar 12, 2023Bioengineering

FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity

N. Wieder, J. M. Coraor Fried, C. Kim, E.-H. Sidhom, M. R. Brown, J. L. Marshall, C. Arevalo, M. Dvela-Levitt, M. Kost-Alimova, J. Sieber, K. R. Gabriel, J. Pacheco, C. B. Clish, H. S. Abbasi, S. Singh, , A. Greka

FALCON systematically analyzes 61 free fatty acids to identify lipotoxic effects and a novel mediator of lipotoxicity, CMIP, in human pancreatic beta cells.

bioRxiv · Feb 19, 2023Cell Biology

Proteolysis Targeting Chimeras With Reduced Off-targets

T. M. Nguyen, V. Sreekanth, A. Deb, P. Kokkonda, P. K. Tiwari, K. A. Donovan, V. M. Shoba, S. K. Chaudhary, J. A. M. Mercer, S. Lai, A. Sadagopan, M. Jan, E. S. Fischer, D. R. Liu, B. L. Ebert, A. Choudhary

This study develops a platform to identify off-target degradation of ZF proteins by PROTACs and identifies design rules to reduce off-target effects using pomalidomide analogs.

bioRxiv · Nov 18, 2021Pharmacology & Toxicology