A. Choudhary

JAX Animal Behavior System (JABS): A genetics informed, end-to-end advanced behavioral phenotyping platform for the laboratory mouse

The paper introduces JABS, a platform for automated behavioral phenotyping in mice, integrating data acquisition, machine learning, and genetic analysis to improve behavior classification and genetic studies.

Bifunctional small molecules that induce nuclearlocalization and targeted transcriptional regulation

This paper develops bifunctional molecules that induce nuclear localization and transcriptional regulation, showing their potential for therapeutic applications in cancer.

Photoswitchable Molecular Glues Enable Optical Control of Transcription Factor Degradation

This paper introduces PHOIMiDs, photoswitchable immunomodulatory drugs that degrade Ikaros and Aiolos in a light-dependent manner with high selectivity.

A molecular glue approach to control the half-life of CRISPR-based technologies

This paper introduces a molecular glue approach using pomalidomide to control the half-life of CRISPR-based technologies, enabling precise regulation of their activity and therapeutic potential.

Development and applications of chimera platforms for tyrosine phosphorylation

This paper develops two platforms to create chimeric small molecules that induce tyrosine phosphorylation, demonstrating their ability to trigger phosphorylation and biological activities in target proteins.

FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity

FALCON systematically analyzes 61 free fatty acids to identify lipotoxic effects and a novel mediator of lipotoxicity, CMIP, in human pancreatic beta cells.

Fluorescein-based sensors to purify human α-cells for functional and transcriptomic analyses

This study develops a method to purify human α-cells with >97% purity using a fluorescent probe, enabling functional and transcriptomic analyses.

Robust IgM responses following vaccination are associated with prevention of Mycobacterium tuberculosis infection in macaques

This study shows that IV BCG vaccination in macaques induces strong IgM responses associated with reduced Mtb bacterial burden and protection.

Proteolysis Targeting Chimeras With Reduced Off-targets

This study develops a platform to identify off-target degradation of ZF proteins by PROTACs and identifies design rules to reduce off-target effects using pomalidomide analogs.