Author

A. Sadagopan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 3 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

A. Choudhary· 2 shared G.-S. M. Lee· 2 shared J. Li· 2 shared S. R. Viswanathan· 2 shared T. K. Choueiri· 2 shared V. M. Shoba· 2 shared A. Deb· 1 shared A. Imamovic· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersBiochemistry

A. Choudhary

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A genetic basis for cancer sex differences revealed in Xp11 translocation renal cell carcinoma

M. Achom, A. Sadagopan, C. Bao, F. McBride, Q. Xu, P. Konda, R. W. Tourdot, J. Li, M. Nakhoul, D. Gallant, U. A. Ahmed, J. O'Toole, D. Freeman, G.-S. M. Lee, J. Hecht, , S. R. Viswanathan

This study identifies a genetic basis for cancer sex differences in Xp11 translocation renal cell carcinoma by showing a 2:1 female:male ratio in TFE3 fusions involving the inactive X chromosome.

bioRxiv · Aug 4, 2023 · PreprintCancer Biology

Bifunctional small molecules that induce nuclearlocalization and targeted transcriptional regulation

W. J. Gibson, A. Sadagopan, V. M. Shoba, A. Choudhary, M. L. Meyerson, S. L. Schreiber

This paper develops bifunctional molecules that induce nuclear localization and transcriptional regulation, showing their potential for therapeutic applications in cancer.

bioRxiv · Jul 7, 2023Biochemistry

Proteolysis Targeting Chimeras With Reduced Off-targets

T. M. Nguyen, V. Sreekanth, A. Deb, P. Kokkonda, P. K. Tiwari, K. A. Donovan, V. M. Shoba, S. K. Chaudhary, J. A. M. Mercer, S. Lai, A. Sadagopan, M. Jan, E. S. Fischer, D. R. Liu, B. L. Ebert, A. Choudhary

This study develops a platform to identify off-target degradation of ZF proteins by PROTACs and identifies design rules to reduce off-target effects using pomalidomide analogs.

bioRxiv · Nov 18, 2021Pharmacology & Toxicology

Integrative Clinical and Molecular Characterization of Translocation Renal Cell Carcinoma

Z. Bakouny, A. Sadagopan, P. Ravi, N. Y. Metaferia, J. Li, S. AbuHammad, S. Tang, T. Denize, E. R. Garner, X. Gao, D. A. Braun, L. Hirsch, J. A. Steinharter, G. Bouchard, E. Walton, , S. R. Viswanathan

This study characterizes translocation renal cell carcinoma (tRCC) through integrated clinical and molecular analysis of 152 patients, identifying key features like MiT/TFE fusions, NRF2-driven antioxidant response, and differential treatment outcomes.

bioRxiv · Apr 14, 2021Cancer Biology