Author

J. A. Philips

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 3 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Assay:metagenomics· 1

Frequent Co-Authors

P. Chandra· 2 shared A. Brown· 1 shared A. Roth· 1 shared A. Seth· 1 shared E. Mittal· 1 shared G. Yang· 1 shared H. P. Kohio· 1 shared H. Wang· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersMicrobiology

P. Chandra

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Single cell preparations of Mycobacterium tuberculosis damage the mycobacterial envelope and disrupt macrophage interactions

E. Mittal, A. Roth, A. Seth, S. Singamaneni, W. Beatty, J. A. Philips

This study shows that common methods to prepare Mycobacterium tuberculosis for experiments damage the bacterial envelope, alter macrophage responses, and affect bacterial survival.

eLife · Feb 28, 2023Peer-reviewedMicrobiology

Molecular Basis for Interferon-mediated Pathogen Restriction in Human Cells

S. K. Matta, H. P. Kohio, P. Chandra, A. Brown, J. G. Doench, J. A. Philips, S. Ding, L. D. Sibley

This study identifies RNF213 as essential for IFN-gamma-mediated restriction of intracellular pathogens like Toxoplasma gondii and Mycobacterium tuberculosis through ubiquitination, independent of autophagy.

bioRxiv · Oct 21, 2022 · PreprintMicrobiology

Fatty acid oxidation impairs macrophage effector functions that control Mycobacterium tuberculosis

P. Chandra, L. He, M. Zimmerman, G. Yang, S. Koster, M. Ouimet, H. Wang, K. J. Moore, V. Dartois, J. D. Schilling, J. A. Philips

This study shows that blocking fatty acid oxidation in macrophages enhances their ability to control Mycobacterium tuberculosis infection by boosting reactive oxygen species and xenophagy.

bioRxiv · Oct 10, 2019 · PreprintMicrobiology