A cancer cell-intrinsic GOT2-PPARδ axis suppresses antitumor immunity
H. Sanford-Crane, J. Abrego, C. Oon, X. Xiao, S. Nagarajan, S. Bhattacharyya, P. Tontonoz, M. H. Sherman
This study identifies a cancer cell-intrinsic GOT2-PPARδ axis that suppresses antitumor immunity by restricting T cells and promoting immune-suppressive myeloid cells in PDAC.
bioRxiv · Dec 25, 2020 · PreprintCancer Biology