P. Tontonoz

T cell cholesterol transport is a metabolic checkpoint that links intestinal immune responses to dietary lipid absorption

This study identifies Aster-A as a cholesterol transporter in T cells that regulates immune signaling and metabolic responses by controlling membrane cholesterol levels.

Defining the Cell Surface Cysteinome using Two-step Enrichment Proteomics

The paper introduces a two-stage enrichment method called Cys-Surf to profile the cell surface cysteinome, identifying 821 ligandable cysteines and redox-sensitive residues with functional implications.

Aster-dependent non-vesicular transport facilitates dietary cholesterol uptake

The paper identifies the Aster pathway as critical for dietary cholesterol uptake and shows it can be targeted with a small molecule inhibitor.

Polarized Mechanosensitive Signaling Domains Protect Arterial Endothelial Cells Against Inflammation

The paper shows that polarized mechanosensitive domains in endothelial cells mediate anti-inflammatory signaling under high shear stress.

A cancer cell-intrinsic GOT2-PPARδ axis suppresses antitumor immunity

This study identifies a cancer cell-intrinsic GOT2-PPARδ axis that suppresses antitumor immunity by restricting T cells and promoting immune-suppressive myeloid cells in PDAC.

The Lands cycle modulates plasma membrane lipid organization and insulin sensitivity in skeletal muscle

The study identifies LPCAT3 as a key regulator of plasma membrane lipid organization and insulin sensitivity in skeletal muscle, showing its role in modulating lipid metabolism and insulin action.

Single Cell Analysis Reveals Immune Cell-Adipocyte Crosstalk Regulating the Transcription of Thermogenic Adipocytes

The paper identifies immune cell-adipocyte communication regulating thermogenic adipocyte transcription through single-cell analysis in mice.