Author

M. H. Sherman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cancer & tumor microenvironment· 3 Research Focus:cell type annotation· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

C. Oon· 3 shared S. Bhattacharyya· 3 shared H. Sanford-Crane· 2 shared W. Horton· 2 shared A. Heguy· 1 shared A. Kothari· 1 shared A. Sattler· 1 shared A. Tsirigos· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersCancer Biology

C. Oon

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Author profile →

4 papers

Recent·Most cited

Single-Cell RNA Sequencing Reveals the Effects of Chemotherapy on Human Pancreatic Adenocarcinoma and its Tumor Microenvironment

G. Werba, D. Weissinger, E. A. Kawaler, E. Zhao, D. Kalfakakou, S. Dhara, G. Oh, X. Jing, N. Beri, L. Khanna, T. Gonda, P. Oberstein, C. Hajdu, C. A. Loomis, A. Heguy, , D. M. Simeone

This study uses single-cell RNA sequencing to analyze how chemotherapy affects PDAC tumor cells and their microenvironment, finding limited transcriptional shifts and reduced TIGIT-mediated immune checkpoint activity.

bioRxiv · May 24, 2022Cancer Biology

Mesenchymal Lineage Heterogeneity Underlies Non-Redundant Functions of Pancreatic Cancer-Associated Fibroblasts

E. J. Helms, M. W. Berry, R. C. Chaw, C. C. DuFort, D. Sun, M. K. Onate, C. Oon, S. Bhattacharyya, H. Sanford-Crane, W. Horton, J. M. Finan, A. Sattler, R. Makar, D. W. Dawson, Z. Xia, , M. H. Sherman

The paper identifies a minor subset of pancreatic cancer-associated fibroblasts (CAFs) derived from pancreatic stellate cells (PSCs) that have non-redundant functions in shaping the tumor microenvironment.

Cancer Discovery · Sep 21, 2021Peer-reviewedCancer Biology

A cancer cell-intrinsic GOT2-PPARδ axis suppresses antitumor immunity

H. Sanford-Crane, J. Abrego, C. Oon, X. Xiao, S. Nagarajan, S. Bhattacharyya, P. Tontonoz, M. H. Sherman

This study identifies a cancer cell-intrinsic GOT2-PPARδ axis that suppresses antitumor immunity by restricting T cells and promoting immune-suppressive myeloid cells in PDAC.

bioRxiv · Dec 25, 2020 · PreprintCancer Biology

Acidic fibroblast growth factor underlies microenvironmental regulation of MYC in pancreatic cancer

S. Bhattacharyya, C. Oon, A. Kothari, W. Horton, J. Link, R. C. Sears, M. H. Sherman

This study identifies FGF1 from cancer-associated fibroblasts as a paracrine regulator of MYC in pancreatic cancer, showing its role in MYC stability and tumor formation.

bioRxiv · Jul 22, 2019Cancer Biology