R. Hauschild

Unveiling the ultrastructural landscape of native extracellular matrix via lift-out cryo-FIBSEM and cryo-ET

This paper develops a 3D-ECM platform to visualize native extracellular matrix structures using cryo-FIBSEM and cryo-ET, revealing new insights into ECM composition and organization.

Adaptive Pathfinding by Nucleokinesis during Amoeboid Migration

This study shows that amoeboid cells use nucleokinesis, a process of nuclear repositioning, to adaptively navigate heterogeneous microenvironments by reorienting between competing signals.

Multi-tier mechanics control stromal adaptations in swelling lymph nodes

The paper investigates how lymph nodes accommodate size increases during immune challenges by analyzing biomechanical adaptations of fibroblastic reticular cells and fibroblasts.

Mechanosensitivity of amoeboid cells crawling in 3D

This study shows how amoeboid cells use WASp-driven actin spikes to push against mechanical loads in 3D environments, enabling efficient migration through dense tissues.

Dendritic cell actin dynamics controls T cell priming efficiency at the immunological synapse

This study shows that dendritic cell actin dynamics, regulated by the WAVE complex, influence T cell priming efficiency at the immunological synapse by modulating synaptic structure and adhesion.

3D printed cell culture grid holders for improved cellular specimen preparation in cryo-electron microscopy

This paper introduces 3D printed grid holders to improve cellular specimen preparation for cryo-EM by increasing reproducibility, throughput, and resource efficiency.

Adhesion-free cell migration by topography-based force transduction

This study shows leukocytes can migrate without adhesion by using substrate topography to transduce force from actin retrograde flow.

Microtubules control cellular shape and coherence in amoeboid migrating cells

This study shows that microtubules regulate protrusion retraction in migrating cells by controlling myosin II contractility through Lfc, maintaining cell shape and coherence.

Live Tracking Of Moving Samples In Confocal Microscopy For Vertically Grown Plant Roots

The paper develops a confocal microscope setup and software for tracking moving samples, enabling long-term observation of root growth and cell migration in plants and zebrafish embryos.