Antigen presentation by tumor-associated macrophages drives tumor-infiltrating T cells from a progenitor exhaustion state to terminal exhaustion
J. Waibl Polania, A. M. Hoyt-Miggelbrink, W. H. Tomaszewski, L. P. Wachsmuth, S. J. Lorrey, D. S. Wilkinson, E. C. Lerner, K. Woroniecka, J. B. Finlay, K. Ayasoufi, P. E. Fecci
The paper identifies tumor-associated macrophages as key drivers of T cell exhaustion transition, showing their role in shifting progenitor exhausted T cells to terminal exhaustion and impacting immunotherapy response.
bioRxiv · Aug 11, 2023 · PreprintImmunology