Author

S. J. Lorrey

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

J. Waibl Polania· 2 shared K. Ayasoufi· 2 shared P. E. Fecci· 2 shared A. Hawley· 1 shared A. Hoyt-Miggelbrink· 1 shared A. M. Hoyt-Miggelbrink· 1 shared A. Patel· 1 shared C. Neff· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersImmunology

J. Waibl Polania

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2 papers

Recent·Most cited

Glioblastoma and other intracranial tumors elicit systemic sympathetic hyperactivity that limits immunotherapeutic responses

S. J. Lorrey, L. Wachsmuth, J. Finlay, C. Neff, K. Ayasoufi, J. Waibl Polania, A. Hoyt-Miggelbrink, M. Price, L. Rein, S. Dell, R. Reesman, X. Cui, A. Hawley, E. Lerner, D. Wilkinson, , P. E. Fecci

This study shows that intracranial tumors cause systemic sympathetic hyperactivity, impairing T cell function and limiting immunotherapy, and that beta-adrenergic blockade improves outcomes in mouse models and human patients.

bioRxiv · Nov 2, 2023 · PreprintImmunology

Antigen presentation by tumor-associated macrophages drives tumor-infiltrating T cells from a progenitor exhaustion state to terminal exhaustion

J. Waibl Polania, A. M. Hoyt-Miggelbrink, W. H. Tomaszewski, L. P. Wachsmuth, S. J. Lorrey, D. S. Wilkinson, E. C. Lerner, K. Woroniecka, J. B. Finlay, K. Ayasoufi, P. E. Fecci

The paper identifies tumor-associated macrophages as key drivers of T cell exhaustion transition, showing their role in shifting progenitor exhausted T cells to terminal exhaustion and impacting immunotherapy response.

bioRxiv · Aug 11, 2023 · PreprintImmunology