Author

P. T. Fueger

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 4 Cell Biology· 2 Pharmacology & Toxicology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Organism:mouse· 7 Research Focus:cell type annotation· 4 Research Focus:differential expression· 4 Assay:bulk RNA-seq· 3 Research Focus:cell signaling & trafficking· 3 Assay:proteomics· 3 Research Focus:cancer & tumor microenvironment· 2

Frequent Co-Authors

J. M. Irimia· 4 shared B. M. Bauer· 3 shared E. Bloom-Saldana· 3 shared Y.-C. Chen· 3 shared A. J. Lutkewitte· 2 shared H. D. Basavarajappa· 2 shared J.-W. Jeong· 2 shared M. M. Saenz· 2 shared

Activity by Year

2020-2023 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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4 shared papersPhysiology

J. M. Irimia

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Author profile →

9 papers

Recent·Most cited

Pharmacokinetics of Extended-release Buprenorphine (Ethiqa) in Female Yorkshire Swine (Sus scrofa domestica)

L. Stevey-Rindenow, M. M. Saenz, V. La, C. Franklin, A. Aycock-Williams, P. T. Fueger

This study examines the pharmacokinetics of extended-release buprenorphine in female Yorkshire swine, finding therapeutic plasma concentrations maintained for 96 hours after subcutaneous administration.

bioRxiv · Oct 4, 2023Pharmacology & Toxicology

Longitudinal analysis of a dietary mouse model of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH)

M. M. Saenz, J. C. McDonough, E. Bloom-Saldana, J. M. Irimia, E. L. Cauble, A. Castillo, P. T. Fueger, L. S. Trevino

This study tracks histopathological, biochemical, transcriptomic, and microbiome changes in mice fed a NASH-promoting diet over 30 weeks, revealing progressive NAFLD development and immune/xenobiotic gene expression changes.

bioRxiv · May 19, 2023 · PreprintPhysiology

Dose-dependent progression of multiple low dose streptozotocin-induced diabetes in mice

B. M. Bauer, S. Bhattacharya, E. Bloom-Saldana, J. M. Irimia, P. T. Fueger

This study compares the effects of two low-dose streptozotocin regimens in mice, showing distinct glucose tolerance, beta cell function, and transcriptional changes.

bioRxiv · Apr 8, 2023Physiology

Pancreatic loss of Mig6 alters murine endocrine cell fate and protects functional beta cell mass in an STZ-induced model of diabetes

B. M. Bauer, J. M. Irimia, E. Bloom-Saldana, J.-W. Jeong, P. T. Fueger

This study shows that pancreatic loss of Mig6 increases beta cell mass and improves glucose tolerance in a diabetes model, but beta cell-specific loss of Mig6 does not provide similar protection.

bioRxiv · Apr 7, 2023 · PreprintPhysiology

Pancreatic Deletion of Mitogen-inducible Gene 6 Promotes Beta Cell Proliferation Following Destruction

K. El, B. M. Bauer, Y.-C. Chen, J.-W. Jeong, P. T. Fueger

This study shows that deleting Mig6 in pancreatic cells enhances beta cell proliferation and glucose tolerance after beta cell destruction in a T1D model.

bioRxiv · Jan 30, 2023 · PreprintCell Biology

Pharmacokinetics of Sustained-Release Buprenorphine and Extended-Release Buprenorphine in Mice with Surgical Catheterization

M. Saenz, E. A. Bloom-Saldana, T. Synold, R. W. Ermel, P. T. Fueger, J. B. Finlay

This study compares the pharmacokinetics and therapeutic efficacy of sustained-release and extended-release buprenorphine in surgically catheterized mice, showing both maintain therapeutic concentrations for 72 hours.

bioRxiv · Mar 14, 2022Pharmacology & Toxicology

Glucolipotoxicity-induced Mig6 desensitizes EGFR signaling and promotes pancreatic beta cell death

Y.-C. Chen, A. J. Lutkewitte, H. D. Basavarajappa, P. T. Fueger

This study shows that Mig6, induced by glucolipotoxicity, inhibits EGFR signaling and promotes beta cell death in type 2 diabetes.

bioRxiv · Nov 24, 2020Cell Biology

Mig6 decreases hepatic EGFR activation and survival during saturated fatty acid-induced endoplasmic reticulum stress

A. J. Lutkewitte, Y.-C. Chen, J. L. Hansen, P. T. Fueger

This study shows Mig6 increases during ER stress in obesity and diabetes, reducing EGFR activation and hepatocyte survival.

bioRxiv · Nov 24, 2020 · PreprintPhysiology

The adaptor protein NumbL is involved in the control of glucolipotoxicity-induced pancreatic beta cell apoptosis

H. D. Basavarajappa, J. M. Irimia, P. T. Fueger

This study identifies NumbL as a mediator of glucolipotoxicity-induced beta cell apoptosis by interacting with Mig6 and TRAF6 to activate NF-κB signaling.

bioRxiv · Aug 16, 2020Biochemistry