Human papilloma virus E6 regulates therapy responses in oropharyngeal cancer by repressing the PGC-1α/ERRα axis
M. K. Sannigrahi, P. Rajagopalan, L. Lai, X. Liu, V. Sahu, H. Nakagawa, J. B. Jalaly, R. M. Brody, I. M. Morgan, B. E. Windle, X. Wang, P. A. Gimotty, D. P. Kelly, E. A. White, D. Basu
This study shows that HPV E6 reduces mitochondrial antioxidant capacity and therapy resistance in oropharyngeal cancer by suppressing the PGC-1α/ERRα pathway.
bioRxiv · May 4, 2022 · PreprintCancer Biology