E. A. White

HPV18 E7 inhibits LATS1 kinase and activates YAP1 by degrading PTPN14

This study shows HPV18 E7 degrades PTPN14, inhibits LATS1 kinase, and activates YAP1, which inhibits keratinocyte differentiation.

Systematic analysis of IL-1 cytokine signaling suppression by high-risk HPV oncoproteins

This study shows that HPV16 E6 and E7 oncoproteins suppress IL-1β signaling in both early and late stages of HPV-induced carcinogenesis by upregulating suppressors like SIGIRR.

ZER1 contributes to the carcinogenic activity of high-risk HPV E7 proteins

This study identifies ZER1 as a host protein that contributes to the carcinogenic activity of HPV16 E7 by promoting cell growth and cancer cell survival.

Human papilloma virus E6 regulates therapy responses in oropharyngeal cancer by repressing the PGC-1α/ERRα axis

This study shows that HPV E6 reduces mitochondrial antioxidant capacity and therapy resistance in oropharyngeal cancer by suppressing the PGC-1α/ERRα pathway.

YAP1 Activation by Human Papillomavirus E7 Promotes Basal Cell Identity in Squamous Epithelia

This study shows that HPV E7 activates YAP1, promoting basal cell identity and contributing to HPV persistence and carcinogenesis.

T2R bitter taste receptors regulate apoptosis and may be associated with survival in head and neck squamous cell carcinoma

This study shows T2R bitter taste receptors in HNSCC promote apoptosis and are linked to better patient survival.

A conserved amino acid in the C-terminus of HPV E7 mediates binding to PTPN14 and repression of epithelial differentiation

This paper identifies a conserved arginine residue in HPV E7 that mediates PTPN14 binding and repression of keratinocyte differentiation, contributing to HPV carcinogenesis.

Identifying predictors of HPV-related head and neck squamous cell carcinoma progression and survival through patient-derived models

This study identifies predictors of HPV-related head and neck squamous cell carcinoma progression and survival using patient-derived models and finds associations between mutational burden and E2F target dysregulation with clinical outcomes.

PTPN14 Degradation by High-Risk Human Papillomavirus E7 Limits Keratinocyte Differentiation and Contributes to HPV-Mediated Oncogenesis

This study shows that high-risk HPV E7 degrades PTPN14, impairing keratinocyte differentiation and contributing to oncogenesis independent of RB1 inactivation.