Author

P. A. Gimotty

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Immunology· 3

Signature Assays, Organisms & Methods

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Organism:human· 6 Approach:experimental assay· 4 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:flow cytometry· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

D. Basu· 3 shared P. Rajagopalan· 3 shared E. A. White· 2 shared H. Nakagawa· 2 shared I. M. Morgan· 2 shared L. Bartolo· 2 shared M. K. Sannigrahi· 2 shared R. M. Brody· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersCancer Biology

D. Basu

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

The pseudokinase Trib1 regulates the transition of exhausted T cells to a KLR+ CD8+ effector state and its deletion improves checkpoint blockade

S. E. McClory, O. Bardhan, K. S. Rome, J. R. Giles, A. E. Baxter, L. Xu, P. A. Gimotty, R. B. Faryabi, E. J. Wherry, W. S. Pear, M. S. Jordan

This study shows that deleting Trib1 shifts exhausted T cells to a KLR+ CD8+ effector state, enhancing viral clearance and checkpoint inhibitor response.

bioRxiv · Feb 16, 2023Immunology

Cancer type-specific prioritization strategy for targetable dependencies developed from the DepMap profile of head and neck cancer

A. C. Cao, M. K. Sannigrahi, P. Rajagopalan, R. M. Brody, L. Raghav, P. A. Gimotty, D. Basu

This paper identifies cancer type-specific gene dependencies in head and neck cancer using DepMap CRISPR screens, highlighting novel therapeutic targets and synthetic lethalities.

bioRxiv · Jun 12, 2022 · PreprintCancer Biology

Human papilloma virus E6 regulates therapy responses in oropharyngeal cancer by repressing the PGC-1α/ERRα axis

M. K. Sannigrahi, P. Rajagopalan, L. Lai, X. Liu, V. Sahu, H. Nakagawa, J. B. Jalaly, R. M. Brody, I. M. Morgan, B. E. Windle, X. Wang, P. A. Gimotty, D. P. Kelly, E. A. White, D. Basu

This study shows that HPV E6 reduces mitochondrial antioxidant capacity and therapy resistance in oropharyngeal cancer by suppressing the PGC-1α/ERRα pathway.

bioRxiv · May 4, 2022 · PreprintCancer Biology

SARS-CoV-2-specific T cells in unexposed adults display broad trafficking potential and cross-react with commensal antigens

L. Bartolo, S. Afroz, Y.-G. Pan, R. Xu, L. Williams, C.-F. Lin, E. S. Friedman, P. A. Gimotty, G. D. Wu, L. Su

bioRxiv · Nov 29, 2021Immunology

Vaccination reshapes the virus-specific T cell repertoire in unexposed adults

Y.-G. Pan, B. Aiamkitsumrit, L. Bartolo, Y. Wang, C. Lavery, A. Marc, P. V. Holec, C. G. Rappazzo, T. Eilola, P. A. Gimotty, S. E. Hensley, R. Antia, V. I. Zarnitsyna, M. E. Birnbaum, L. F. Su

This study examines how pre-existing T cell characteristics influence the immune response to a yellow fever vaccine, finding that memory T cells and rare populations shape post-vaccination responses.

bioRxiv · Oct 1, 2020Immunology

Identifying predictors of HPV-related head and neck squamous cell carcinoma progression and survival through patient-derived models

N. D. Facompre, P. Rajagopalan, V. Sahu, A. T. Pearson, K. T. Montone, C. D. James, F. O. Gleber-Netto, G. S. Weinstein, J. Jalaly, A. Lin, A. K. Rustgi, H. Nakagawa, J. A. Califano, C. R. Pickering, E. A. White, , D. Basu

This study identifies predictors of HPV-related head and neck squamous cell carcinoma progression and survival using patient-derived models and finds associations between mutational burden and E2F target dysregulation with clinical outcomes.

bioRxiv · Jun 17, 2019Cancer Biology