Targeting Allostery in the Dynein Motor Domain with Small Molecule Inhibitors
C. C. Santarossa, K. Mickolajczyk, J. B. Steinman, L. Urnavicius, N. Chen, Y. Fukase, Y. Hirata, N. Coudray, D. C. Ekiert, G. Bhabha, T. M. Kapoor
This study develops small molecule inhibitors targeting allostery in dynein motor domains by inhibiting regulatory ATPase sites rather than the main catalytic site.
bioRxiv · Sep 22, 2020Biochemistry