Author

Y. Hirata

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Biochemistry· 1 Cell Biology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Research Focus:drug response / drug discovery· 2 Organism:Arabidopsis· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

H. Ueki· 2 shared K. Iwatsuki-Horimoto· 2 shared M. Imai· 2 shared M. Ito· 2 shared S. Iida· 2 shared T. Suzuki· 2 shared Y. Kawaoka· 2 shared a. matsuzawa· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersMicrobiology

H. Ueki

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Combination therapy with oral antiviral and anti-inflammatory drugs improves the efficacy of delayed treatment in severe COVID-19

M. Sasaki, S. Iida, Y. Hirata, S. Kusakabe, K. Konishi, Y. Itakura, K. Tabata, M. Kishimoto, H. Kobayashi, T. Ariizumi, K. Intaruck, H. Nobori, S. Toba, A. Sato, K. Matsuno, , H. Sawa

This study shows that combining an oral antiviral with a corticosteroid improves treatment outcomes in delayed SARS-CoV-2 infection in hamsters compared to monotherapy.

bioRxiv · Jun 20, 2023Microbiology

Lipid peroxidation increases membrane tension, Piezo1 gating and cation permeability to execute ferroptosis

S. Grinstein, Y. Hirata, B. E. Steinberg, A. Volchuk, a. matsuzawa, R. Cai, S. A. Freeman

This study shows that lipid peroxidation during ferroptosis increases membrane tension, activates Piezo1 and TRP channels, and causes cation permeability, leading to cell death.

bioRxiv · Oct 31, 2022Cell Biology

Can SARS-CoV-2 transmit from a dead body?

K. Iwatsuki-Horimoto, H. Ueki, M. Ito, S. Nagasawa, Y. Hirata, K. Hashizume, K. Ushiwata, H. Iwase, Y. Makino, T. Ushiku, S. Akitomi, M. Imai, H. Saitoh, Y. Kawaoka

This study investigates SARS-CoV-2 transmission from dead bodies using a hamster model, finding that transmission is possible but can be prevented by postmortem care and embalming.

bioRxiv · Aug 29, 2022 · PreprintMicrobiology

Characterization of SARS-CoV-2 Omicron BA.2.75 clinical isolates

R. Uraki, S. Iida, P. J. Halfmann, S. Yamayoshi, Y. Hirata, K. Iwatsuki-Horimoto, M. Kiso, M. Ito, Y. Furusawa, H. Ueki, Y. Sakai-Tagawa, M. Kuroda, T. Maemura, T. Kim, S. Mine, , Y. Kawaoka

This study evaluates the replicative ability and pathogenicity of SARS-CoV-2 BA.2.75 isolates in Syrian hamsters, finding higher lung replication and focal pneumonia compared to BA.2 and BA.5.

bioRxiv · Aug 26, 2022 · PreprintMicrobiology

Targeting Allostery in the Dynein Motor Domain with Small Molecule Inhibitors

C. C. Santarossa, K. Mickolajczyk, J. B. Steinman, L. Urnavicius, N. Chen, Y. Fukase, Y. Hirata, N. Coudray, D. C. Ekiert, G. Bhabha, T. M. Kapoor

This study develops small molecule inhibitors targeting allostery in dynein motor domains by inhibiting regulatory ATPase sites rather than the main catalytic site.

bioRxiv · Sep 22, 2020Biochemistry

A mobile ELF4 delivers circadian temperature information from shoots to roots

W. W. Chen, N. Takahashi, Y. Hirata, D. Nusinow, S. Kay, P. Mas

This study identifies ELF4 as a mobile protein that transmits temperature signals from shoots to roots, regulating the root circadian clock based on temperature.

bioRxiv · Apr 18, 2019Plant Biology