Author

L. Urnavicius

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 5

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 5 Organism:human· 3 Research Focus:chromatin & epigenetic regulation· 2 Assay:cryo-EM· 2 Research Focus:protein structure prediction· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

T. M. Kapoor· 4 shared A. Aher· 2 shared B. T. Chait· 2 shared K. R. Molloy· 2 shared M. Wieczorek· 2 shared S.-C. Ti· 2 shared A. Xue· 1 shared C. C. Santarossa· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersBiochemistry

T. M. Kapoor

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Structure of the γ-tubulin ring complex-capped microtubule

A. Aher, L. Urnavicius, A. Xue, K. Neselu, T. Kapoor

The paper reports the structure of the γ-tubulin ring complex-capped microtubule, revealing how it nucleates and stabilizes 13-protofilament microtubules.

bioRxiv · Nov 20, 2023Biochemistry

Allosteric activation of VCP, a AAA unfoldase, by small molecule mimicry

N. H. Jones, Q. Liu, L. Urnavicius, N. E. Dahan, L. E. Vostal, T. M. Kapoor

This paper identifies VA1, a small molecule that activates VCP/p97, and reveals its allosteric mechanism through cryo-EM structures and mutagenesis studies.

bioRxiv · Oct 2, 2023 · PreprintBiochemistry

Targeting Allostery in the Dynein Motor Domain with Small Molecule Inhibitors

C. C. Santarossa, K. Mickolajczyk, J. B. Steinman, L. Urnavicius, N. Chen, Y. Fukase, Y. Hirata, N. Coudray, D. C. Ekiert, G. Bhabha, T. M. Kapoor

This study develops small molecule inhibitors targeting allostery in dynein motor domains by inhibiting regulatory ATPase sites rather than the main catalytic site.

bioRxiv · Sep 22, 2020Biochemistry

Biochemical reconstitutions reveal principles of human γ-TuRC assembly and function

M. Wieczorek, S.-C. Ti, L. Urnavicius, K. R. Molloy, A. Aher, B. T. Chait, T. M. Kapoor

This paper reconstitutes the human γ-TuRC and analyzes its structure and function, showing that the lumenal bridge is essential for microtubule nucleation.

bioRxiv · Sep 21, 2020Biochemistry

Asymmetric molecular architecture of the human γ-tubulin ring complex

M. Wieczorek, L. Urnavicius, S.-C. Ti, K. R. Molloy, B. T. Chait, T. M. Kapoor

This study presents a cryo-EM structure of the native human γ-tubulin ring complex, revealing its asymmetric architecture and identifying new structural features and interactions.

bioRxiv · Oct 25, 2019Biochemistry