Aspirin-mediated DKK-1 increase rescues Wnt-driven stem-like phenotype in human intestinal organoids
K. Dunbar, A. Valanciute, V. Rajasekaran, T. Jamieson, P. Freile Vinuela, A. Lima, J. Blackmur, A.-M. Ochocka-Fox, M. J. Arends, O. J. Sansom, K. B. Myant, S. M. Farrington, M. G. Dunlop, F. V. N. Din
The paper shows aspirin reduces Wnt-driven stem-like traits in intestinal organoids by increasing DKK-1, suggesting a mechanism for its anti-cancer effects.
bioRxiv · Oct 17, 2019 · PreprintCancer Biology