Author

J. C. Genereux

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biochemistry· 2

Signature Assays, Organisms & Methods

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Assay:proteomics· 5 Research Focus:cell signaling & trafficking· 4 Approach:experimental assay· 4 Organism:human· 4 Research Focus:cell type annotation· 3 Research Focus:protein folding & dynamics· 3 Research Focus:clustering· 1 Approach:deep learning· 1

Frequent Co-Authors

M. R. Montoya· 3 shared G. M. Quanrud· 2 shared L. Mei· 2 shared Z. Lyu· 2 shared C. Hong· 1 shared E. M. Smith-Cohen· 1 shared I. C. Romine· 1 shared J. L. Montano· 1 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersBiochemistry

M. R. Montoya

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Author profile →

5 papers

Recent·Most cited

Quantitative Measurement of Secretory Protein Mistargeting by Proximity Labeling and Parallel Reaction Monitoring

Z. Lyu, J. C. Genereux

The paper develops a quantitative method using proximity labeling and parallel reaction monitoring to study secretory protein mistargeting during ER stress, revealing that ER stress alone is not sufficient for pre-QC induction.

bioRxiv · Jul 19, 2023 · PreprintCell Biology

Hspa13 Regulates Endoplasmic Reticulum and Cytosolic Proteostasis Through Modulation of Protein Translocation

M. F. Espinoza, K. K. Nguyen, M. M. Sycks, Z. Lyu, M. R. Montoya, J. C. Genereux

This study shows Hspa13 regulates protein translocation through the Sec61 translocon, affecting ER and cytosolic proteostasis by modulating secretory protein import and maturation.

bioRxiv · Jun 27, 2022Cell Biology

ATF6 Activation Reduces Amyloidogenic Transthyretin Secretion Through Increased Interactions with Endoplasmic Reticulum Proteostasis Factors

J. S. Mezgarzadeh, I. C. Romine, E. M. Smith-Cohen, J. M. Grandjean, J. W. Kelly, J. C. Genereux, L. Wiseman

This study identifies how ATF6 activation reduces amyloidogenic TTR secretion through ER retention mediated by BiP and PDIA4, independent of redox activity.

bioRxiv · Apr 13, 2022Cell Biology

Factors Affecting Protein Recovery During Hsp40 Affinity Profiling

M. R. Montoya, G. M. Quanrud, L. Mei, J. L. Montano, C. Hong, J. C. Genereux

This study evaluates methods to improve Hsp40 affinity profiling for identifying stress-induced misfolded proteins, finding DNAJB8H31Q remains the most effective recognition element under stress.

bioRxiv · Mar 31, 2022Biochemistry

Hsp40 Affinity to Identify Proteins Destabilized by Cellular Toxicant Exposure

G. M. Quanrud, M. R. Montoya, L. Mei, M. R. Awad, J. C. Genereux

This study uses Hsp40 affinity to identify proteins destabilized by toxicant exposure and validates findings with a proteolysis assay.

bioRxiv · Sep 22, 2021Biochemistry