Author

J. M. Grandjean

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

L. Wiseman· 3 shared E. Powers· 2 shared J. W. Kelly· 2 shared A. Galmozzi· 1 shared A. Madhavan· 1 shared A. Sukiasyan· 1 shared B. P. Kok· 1 shared B. Rius· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersBiochemistry

L. Wiseman

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

BiochemistrybioRxivPreprintJan 16, 2023

Divergent Proteome Reactivity Influences Arm-Selective Activation of Pharmacological Endoplasmic Reticulum Proteostasis Regulators

G. M. Kline, R. J. Paxman, C.-Y. Lin…·J. W. Kelly

This study shows that AA132, a compound with a 2-amino-p-cresol substructure, globally activates all three UPR arms by covalently modifying ER PDIs, while AA147 selectively activates the ATF6 arm.

DOI 10.1101/2023.01.16.524237

proteomicsexperimental assay

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Cell BiologybioRxivApr 13, 2022

ATF6 Activation Reduces Amyloidogenic Transthyretin Secretion Through Increased Interactions with Endoplasmic Reticulum Proteostasis Factors

J. S. Mezgarzadeh, I. C. Romine, E. M. Smith-Cohen…·L. Wiseman

This study identifies how ATF6 activation reduces amyloidogenic TTR secretion through ER retention mediated by BiP and PDIA4, independent of redox activity.

DOI 10.3390/cells11101661

humanproteomics

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PhysiologybioRxivDec 3, 2020

Pharmacologic IRE1/XBP1s Activation Promotes Systemic Adaptive Remodeling in Obesity

A. Madhavan, B. P. Kok, J. M. Grandjean…·L. Wiseman

This study shows that pharmacologic activation of IRE1/XBP1s signaling in obese mice improves glucose metabolism, insulin action, and reduces hepatic steatosis and inflammation.

DOI 10.1038/s41467-022-28271-2

mouseexperimental assay

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