Z. Lyu

Structural Basis for the Activation of Proteinase-Activated Receptors (PARs) by Endogenous Ligands

This study presents structural insights into PAR1 and PAR2 activation by endogenous ligands, revealing a novel mechanism and potential targets for therapeutic development.

E. coli FtsN coordinates synthesis and degradation of septal peptidoglycan by partitioning between a synthesis track and a denuded glycan track

Salmonella Typhimurium infection inhibits macrophage IFNbeta signaling in a TLR4-dependent manner

This study shows Salmonella Typhimurium inhibits macrophage IFNbeta signaling via TLR4, but IFNbeta does not affect host defense against STm.

FtsZ-mediated spatial-temporal control over septal cell wall synthesis

This paper shows FtsZ treadmilling acts as a template and conveyor to organize cell wall synthesis during bacterial division, with roles changing over time.

Deficiency in ribosome biogenesis causes streptomycin resistance and impairs motility in Salmonella

This study identifies RimP as a ribosome assembly factor in Salmonella that contributes to streptomycin resistance and motility impairment.

BBQ methods: Streamlined workflows for Bacterial Burden Quantification in infected cells by confocal microscopy

This paper introduces two automated methods for quantifying bacterial burden in macrophages using confocal microscopy, validated with Salmonella and Mycobacterium models.

Integrative phenotypic-transcriptomic analysis of soybean plants subjected to multifactorial stress combination

This study investigates the effects of multifactorial stress combinations on soybean plants, revealing negative cumulative impacts and unique transcriptomic responses in different tissues.

Quantitative Measurement of Secretory Protein Mistargeting by Proximity Labeling and Parallel Reaction Monitoring

The paper develops a quantitative method using proximity labeling and parallel reaction monitoring to study secretory protein mistargeting during ER stress, revealing that ER stress alone is not sufficient for pre-QC induction.

Steric-free bioorthogonal profiling of cellular acetylation and glycosylation via a fluorine-selenol displacement reaction (FSeDR)

This paper introduces a fluorine-selenol displacement reaction (FSeDR) to label and image acetylation and glycosylation, and uses it with SILAC proteomics to profile acetylation substrates in prostate cancer cells.

A Long-Circulating Vector for Aptamers Based upon Polyphosphodiester-Backboned Molecular Brushes

This paper develops a long-circulating molecular brush to enhance aptamer stability and bioactivity in vivo.

Hspa13 Regulates Endoplasmic Reticulum and Cytosolic Proteostasis Through Modulation of Protein Translocation

This study shows Hspa13 regulates protein translocation through the Sec61 translocon, affecting ER and cytosolic proteostasis by modulating secretory protein import and maturation.

FtsN activates septal cell wall synthesis by forming a processive complex with the septum-specific peptidoglycan synthase in E. coli

This study shows FtsN activates septal peptidoglycan synthesis by forming a processive complex with FtsWI on the sPG-track, rather than displacing FtsWI from the Z-track.

Simulations of fluorescence imaging in the oral cavity

The paper simulates fluorescence imaging in the oral cavity using a 3D model and compares simulated data with real camera data to quantify porphyrin fluorescence relative to other fluorophores.

Unprotected Peptide Macrocyclization and Stapling via A Fluorine-Thiol Displacement Reaction

This paper introduces a new peptide stapling method using fluorine-thiol displacement reaction, showing improved stability, affinity, and cell permeability compared to traditional methods.

Steric-Free Bioorthogonal Labeling of Acetylation Substrates Based on a Fluorine-Thiol Displacement Reaction (FTDR)

This paper introduces a novel bioorthogonal reaction, FTDR, for selectively labeling acetylation substrates using fluorine-thiol displacement, enabling detection and imaging of acetylated proteins.

Treadmilling FtsZ polymers drive the directional movement of sPG-synthesis enzymes via a Brownian ratchet mechanism

This study shows FtsZ treadmilling drives directional movement of sPG-synthesis enzymes via a Brownian ratchet mechanism, controlling enzyme processivity and sPG synthesis.

Data-driven models reveal mutant cell behaviors important for myxobacterial aggregation

The paper uses data-driven models to identify key mutant cell behaviors in Myxococcus xanthus that contribute to aggregation, showing that imperfect behaviors can still support multicellular self-organization.

Aging immune system-related blood cell DNA methylation can predict the onset of early stage colorectal cancer

This study identifies DNA methylation of DZIP3 as a marker for early stage colorectal cancer, linked to aging and immune cell composition.

Agonist binding affinity determines palmitoylation of the glucagon-like peptide-1 receptor and its functional interaction with plasma membrane nanodomains in pancreatic beta cells

This study shows that agonist binding affinity affects GLP-1R palmitoylation, nanodomain clustering, and signaling in pancreatic beta cells, influencing insulin secretion.