Author

J. C. Patterson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:perturbation response prediction· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

M. B. Yaffe· 2 shared A. C. Palmer· 1 shared A. Dinh· 1 shared A. Izrael-Tomasevic· 1 shared A. M. Hosios· 1 shared A. Varkaris· 1 shared C. M. Rose· 1 shared D. J. Einstein· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersCancer Biology

M. B. Yaffe

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Author profile →

2 papers

Recent·Most cited

An RNA Damage Response Network Mediates the Lethality of 5-FU in Clinically Relevant Tumor Types

J.-K. Chen, K. A. Merrick, Y. W. Kong, A. Izrael-Tomasevic, G. Eng, E. D. Handly, J. C. Patterson, L. Suarez-Lopez, A. M. Hosios, A. Dinh, D. S. Kirkpatrick, K. Yu, C. M. Rose, J. M. Hernandez, H. Hwangbo, , M. B. Yaffe

This paper shows 5-FU's lethality in tumors is due to an RNA damage response, not DNA damage, and that targeting this response could improve cancer therapy.

bioRxiv · Apr 28, 2023 · PreprintCancer Biology

Polo-like kinase-1 Inhibitors and the Antiandrogen Abiraterone Synergistically Disrupt Mitosis and Kill Cancer Cells of Disparate Origin Independently of Androgen Receptor Signaling

J. C. Patterson, A. Varkaris, P. J. P. Croucher, M. Ridinger, S. Darlymple, M. Nouri, F. Xie, S. Varmeh, O. Jonas, M. A. Whitman, S. Chen, S. Rashed, L. Makusha, J. Luo, J. T. Isaacs, , M. B. Yaffe

This study shows that combining Plk1 inhibitors with abiraterone synergistically kills cancer cells across tumor types, independent of androgen receptor signaling, through mitotic disruption.

bioRxiv · May 12, 2022 · PreprintCancer Biology