Author

A. M. Hosios

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

M. Vander Heiden· 2 shared A. C. Palmer· 1 shared A. Dinh· 1 shared A. Izrael-Tomasevic· 1 shared A. M. Westermark· 1 shared A. Valvezan· 1 shared B. D. Manning· 1 shared B. W. Ji· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersCancer Biology

M. Vander Heiden

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

An RNA Damage Response Network Mediates the Lethality of 5-FU in Clinically Relevant Tumor Types

J.-K. Chen, K. A. Merrick, Y. W. Kong, A. Izrael-Tomasevic, G. Eng, E. D. Handly, J. C. Patterson, L. Suarez-Lopez, A. M. Hosios, A. Dinh, D. S. Kirkpatrick, K. Yu, C. M. Rose, J. M. Hernandez, H. Hwangbo, , M. B. Yaffe

This paper shows 5-FU's lethality in tumors is due to an RNA damage response, not DNA damage, and that targeting this response could improve cancer therapy.

bioRxiv · Apr 28, 2023 · PreprintCancer Biology

The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals

M. E. Torrence, M. R. MacArthur, A. M. Hosios, A. Valvezan, J. M. Asara, J. R. Mitchell, B. D. Manning

This study shows that mTORC1 activates ATF4 to promote protein and glutathione synthesis, distinct from ISR-mediated ATF4 activation.

bioRxiv · Oct 3, 2020Cell Biology

Cancer cells depend on environmental lipids for proliferation when electron acceptors are limited

Z. Li, B. W. Ji, P. D. Dixit, E. C. Lien, K. Tchourine, A. M. Hosios, K. L. Abbott, A. M. Westermark, E. F. Gorodetsky, L. B. Sullivan, M. Vander Heiden, D. Vitkup

This study shows that cancer cells rely on environmental lipids for proliferation under conditions of limited electron acceptors, such as hypoxia or mitochondrial inhibition.

bioRxiv · Jun 8, 2020Cancer Biology