C. M. Rose

Targeting the Hippo pathway in cancers via ubiquitination dependent TEAD degradation

This study identifies RNF146 as an E3 ubiquitin ligase that degrades TEAD proteins via the proteasome, showing that pharmacological induction of TEAD ubiquitination can suppress YAP/TAZ-driven cancer growth.

Increasing the Throughput and Reproducibility of Activity-Based Proteome Profiling Studies with Hyperplexing and Intelligent Data Acquisition

The paper introduces InSeqAPI and PairQuant to enhance ABPP throughput and reproducibility using hyperplexing and IDA, identifying new druggable sites in nuclear proteins.

An RNA Damage Response Network Mediates the Lethality of 5-FU in Clinically Relevant Tumor Types

This paper shows 5-FU's lethality in tumors is due to an RNA damage response, not DNA damage, and that targeting this response could improve cancer therapy.

HLApollo: A superior transformer model for pan-allelic peptide-MHC-I presentation prediction, with diverse negative coverage, deconvolution and protein language features.

HLApollo improves MHC-I peptide presentation prediction with a transformer model, showing better performance than existing methods and offering pan-allelic generalization.

Discovery of prevalent, clinically actionable tumor neoepitopes via integrated biochemical and cell-based platforms

The paper identifies 84 clinically relevant neoepitope-HLA pairs from 37 shared cancer neoantigens using a combination of biochemical assays and computational methods.

Sensitive and quantitative detection of MHC-I displayed neoepitopes using a semi-automated workflow and TOMAHAQ mass spectrometry

The paper develops a semi-automated workflow with TOMAHAQ mass spectrometry to detect and quantify MHC-I displayed neoepitopes in various cell lines.