C. Gibson

Human coronavirus HKU1 recognition of the TMPRSS2 host receptor

This study determines the structure of HKU1 spike RBD bound to TMPRSS2, identifies host receptor usage determinants, and shows the role of antibodies and glycan shielding in neutralization.

pH-Controlled chemoselective rapid azo-coupling reaction (CRACR) enables global profiling of serotonylation proteome in cancer cells

The paper develops a chemical proteomic method to globally profile serotonylation in cancer cells, identifying over 1,000 serotonylated proteins and their modification sites.

Chemical proteomic profiling of protein dopaminylation in colorectal cancer cells

The paper identifies 425 dopaminylated proteins in colorectal cancer cells using a chemical probe, revealing their involvement in nucleic acid metabolism and transcription, and suggests targeting protein dopaminylation as a potential anti-cancer strategy.

AutoXAI4Omics: an Automated Explainable AI tool for Omics and tabular data

AutoXAI4Omics automates and explains ML pipelines for omics and tabular data, enabling interpretable insights for biomarker discovery and phenotype prediction.

Bioorthogonal labeling and enrichment of histone monoaminylation reveal its accumulation and regulatory function in cancer cell chromatin

This study develops chemical probes to label and enrich histone monoaminylation, revealing its enrichment in cancer tissues and its role in chromatin architecture regulation.

Development of Ingenui-T, a Novel Vein-to-Vein Solution for Rapid Autologous CAR T-Cell Manufacturing Starting From Whole Blood, for the Treatment of Autoimmune Diseases

This paper introduces Ingenui-T, a method for rapid CAR T-cell manufacturing from whole blood, showing comparable or better functional activity than conventional methods.

The HCM-Linked Mutation Arg92Leu in TNNT2 Allosterically Alters the cTnC-cTnI Interface and Disrupts the PKA-mediated Regulation of Myofilament Relaxation

This paper investigates how the HCM-linked mutation Arg92Leu in TNNT2 alters the cTnC-cTnI interface, impairing PKA access and causing early diastolic dysfunction.

Multiplexed Amplicon Sequencing Reveals High Sequence Diversity of Antibiotic Resistance Genes in Quebec Sewers

This study uses multiplexed amplicon sequencing to detect sequence variants of antibiotic resistance genes in Quebec sewers, revealing high diversity and varying public health risks.

Antibiotic Resistance Gene Variant Sequencing is Necessary to Reveal the Complex Dynamics of Immigration from Sewers to Activated Sludge

This study investigates ARG immigration dynamics between sewers and activated sludge using sequencing and PCR to show that over 70% of ARGs increase in abundance due to immigration.

Activated Sludge Microbial Community Assembly: The Role of Influent Microbial Community Immigration

This study investigates how influent microbial immigration affects activated sludge communities in wastewater treatment plants, finding that immigrants contribute up to 25% of sequencing reads.

Wastewater Influent Microbial Immigration and Contribution to Resource Consumption in Activated Sludge Using Taxon-Specific Mass-Flow Immigration Model

The paper develops a mass-flow immigration model to quantify influent microorganism immigration efficiency and their contribution to organic substrate consumption in activated sludge.